For Diabetic Foot Ulcer, Heberprot-P is a drug developed by the Center for Genetic Engineering and Biotechnology (CIGB) in 2007 in Cuba.
Diabetes is no longer considered life threatening, nonetheless diabetes and complications due to diabetes, when not under control, remain to be sixth leading cause of death having a higher mortality rate than some cancers such as prostate cancer, breast cancer and colon cancer. Of the most common and most severe complications of diabetes is diabetic foot ulcer which affects an approximate 15% – 20% of people with diabetes and frequently leads to amputation of the lower limb (about 84% of lower extremity amputation is due to this condition).
Diabetic foot ulcer occurs when an ulcer or a wound develop in an area in the lower legs or feet which do not heal or are difficult to treat leading to the exposure of the underlying tissue and becoming susceptible to infections..
Symptoms and Rating
It is not uncommon for people with diabetes to have diabetic foot ulcers for some time without being aware of the development. Some of the symptoms to look for include:
- Thick yellow toenails
- Bad odor from foot
- Tight skin, swelling, redness or other infection symptoms
- Difficulty walking
- Muscle pain or cramps that occur with activity and go away with rest
- discoloration of foot
- Ulcers or sores on the foot
Based on the Wagner Grading System, diabetic foot ulcers are rated between 0 to 5:
- 0 – the foot is normal but is at risk of developing diabetic foot ulcers
- 1 – slight ulceration without infection
- 2 – ulcers with exposed tendons and joints
- 3 – large scale ulceration with infection
- 4 – gangrene of toe(s) or forefoot
- 5 – hind-foot or mid-foot gangrene
CAUSES OF DIABETIC FOOT ULCER
One of the main contributing factors to developing diabetic foot ulcer is peripheral neuropathy.(nerve damage) which arises due to an increase, ever a slight one, in blood sugar level. Due to nerve damage and loss of sensations and the ability to feel pain, foot damage, even from such simple things as pressure from shoes or a small cut, go unnoticed and unprotected resulting in worsening skin loss, blisters and a possibility of a serious infection than may progress in a matter of days.
Narrowing of the arteries (peripheral arterial disease) due to diabetes reduces the blood supply to the feet and is another diabetic complication that contribute to the development of diabetic foot ulcers. An injury to an area with poor blood circulation takes longer to heal and is more difficult to treat making it prone to developing ulcers or gangrene (decomposition of cells due to lack of blood flow).
EPIDERMAL GROWTH FACTOR (EGF) AND DIABETES
A number of studies have shown that diabetic patients have a decreased amount of growth factor concentrations, mainly epidermal growth factor (EGF). Naturally found in the body, EGF stimulate and promote cell growth and regeneration by binding to its receptors -epidermal growth factor receptors (EGFR). Epidermal growth factor acts as a healing agent in that it speeds wound recovery by triggering the synthesis of collagen, elastin and hyaluronic acid.
It follows then for diabetic people with a reduced amount of EGF have more of a likelihood to have impaired wound healing to such extremes as to develop severe complications that may require amputation of the lower limb.
HEBERPROT-P
Heberprot-P is an innovative Cuban product with EGF as the main ingredient given to patients suffering from ulcers that are non healing and non responding to other conventional treatments. It remains to be the only alternative treatment to amputation for diabetic foot ulcers. About 160,000 diabetic foot ulcer patient have been treated with Heberprot-P with success reducing the the risk of amputation by 77%.
The use of Heberprot-P for diabetic foot ulcers has a significant influence on a patient’s overall quality of life in that it not only accelerates the healing process, reduces the number of surgeries needed for the removal of damaged tissue and reduces the risk of development of such complications as infections and gangrene but it also reduces risk of amputation and reduces hospitalization costs.
Heberprot-P is parenteral administered and is free of preservatives. It has demonstrated a favorable risk–benefit and has proven to be well tolerated with mild to moderate side effects, with pain and burning sensation at administration site the most frequent.
According to the World Health Organization (WHO), Heberprot-P was registered in Cuba in 2006 and is now registered in 15 other countries, making it possible to treat more than 100,000 patients; applications for its registration are under review in other countries, including Brazil, China, the Russian Federation, South Africa and the Arab states of the Persian Gulf.
Heberprot-P has won the World Intellectual Property Organization (WIPO) Gold Medal and the Best Young Inventor Award at the International Invention Exhibition in Geneva, Switzerland.
51 comments
Atung Achi
March 31, 2019 at 5:52 am
I enjoyed reading this information about diabetes treatment. How can purchase this drug from Nigeria? I am suffering from type 2
Jing
March 18, 2020 at 4:19 pm
Hi I’m from China and my dad is suffering the foot ulcer now. I think his type 3 and it been almost two months. The wounds are healing very slow pace. I don’t know whether I could buy in China, probably not, if is there has any channels for me to buy the drug? Thanks very much.
CubaHeal Team
March 27, 2020 at 10:58 pm
Dear Jing,
We are forwarding your inquiry to our admin department in order for them to supply with full program details and the cost.
Best regards,
CubaHeal Team
Sushila
August 8, 2024 at 2:42 pm
I enjoy reading information from Toronto very informative
NWAZIRI Sixtus
April 27, 2019 at 8:50 am
Please how can I get this drug in Lagos Nigeria my junior sister is a diabetic patient and she has an ulcer on left hand
CubaHeal
May 22, 2019 at 10:30 pm
Dear NWAZIRI,
Your request has been forwarded to our admin department in order for them to reach out to you.
Best regards,
CubaHeal team
Claudia Ocville
June 6, 2019 at 6:12 am
Please how can I get this drug for my dad .I live at New york
CubaHeal
June 18, 2019 at 3:48 pm
Dear Claudia,
Your inquiry has been forwarded to our admin department in order for them to follow up with you.
Best regards,
CubaHeal Team
Natasha
June 21, 2019 at 1:18 am
How can I get this drug , my uncle is in serious need of this ASAP. Please help
CubaHeal Team
July 19, 2019 at 6:52 pm
Dear Natasha,
Your inquiry has been forwarded to our admin department in order for them to follow up with you.
Best regards,
CubaHeal Team
Eren
November 11, 2024 at 8:17 pm
Bu ilaçı bir hemşire yaraya kullanabilir mi yada Türkiye de hangi doktor yapıyor ?
Acil bir dönüş sağlarsanız
CubaHeal Client Care
December 6, 2024 at 2:02 am
Dear Eren,
Your inquiry had been forwarded to our admin department in order for them to reach out to you with full details of the possible treatment options, the costs, and the steps you are required to complete in order for the admin team to be able to forward your complete medical dossier to the Cuban Medical Authorities (CMA) for evaluation and determination of suitability.
Best regards
mohammed (Last name is withheld for privacy purposes)
August 12, 2019 at 9:30 am
Please how can I get this drug for my dad .I live at india
CubaHeal team
September 28, 2019 at 8:13 pm
Dear Mohammed,
Your inquiry has been forwarded to our admin department in order for them to follow up with you.
Best regards,
CubaHeal Team
Nikola (Last name is withheld for privacy purposes)
September 25, 2019 at 8:48 pm
Hi my name is Nikola and my father has problem with diabetic ulcers and we need this medication how can we get this medication to Serbia?
Please let me know.
Thank you.
CubaHeal team
September 28, 2019 at 7:28 pm
Dear Nikola,
Your inquiry has been forwarded to our admin department in order for them to follow up with you.
Best regards,
CubaHeal Team
David
October 12, 2019 at 6:33 am
Cure for hepatitis b
CubaHeal team
October 24, 2019 at 7:48 pm
Dear David,
We are forwarding your inquiry to our admin department in order for them to follow up with you regarding possible treatment of this condition.
Best regards,
CubaHeal team
Diane
November 1, 2019 at 7:06 am
How can i get this medication?
CubaHeal team
November 18, 2019 at 10:36 pm
Dear Diane,
We are forwarding your inquiry to our admin department in order for them to supply with full program details and the cost.
Best regards,
CubaHeal Team
Heidi (Last name withheld for privacy purposes)
February 10, 2020 at 1:54 am
How can I get treatment with this drug for my mother, she has an ulcer on her large toe and it is dry gangrene. Not infected yet.
CubaHeal team
February 27, 2020 at 4:53 pm
Dear Heidi,
We are forwarding your inquiry to our admin department in order for them to supply with full program details and the cost.
Best regards,
CubaHeal Team
Queen (Last name withheld for privacy purposes)
February 26, 2020 at 9:33 pm
How can it e purchased inUS?
Dango
March 23, 2020 at 12:01 pm
I have suffering from diabetics past two years. Till I am not take medicine. But tring to control. B.Fasting 260. After fasting 400. Medicine are available? I am from India
David (Last name withheld for privacy purposes)
April 29, 2020 at 1:21 am
My name is David Hou and I am from Solomon Islands, my wife is having diabetic and I want to medicine for her. How can I bring it to Solomon Islands? Thanks so much.
David (Last name withheld for privacy purposes)
April 29, 2020 at 4:11 am
Any possibility of getting this drug to Solomon Islands, I’m a diabetic person for 2 years now. And I don’t know what to do.
Thanks so much.
CubaHeal Team
May 4, 2020 at 3:13 pm
Dear David,
We are forwarding your inquiry to our admin department in order for them to supply with full program details and the cost.
Best regards,
CubaHeal Team
Etratia (Last name withheld for privacy purposes)
May 7, 2020 at 9:16 am
How can I get the treatment for my uncle it has already been infected and it sometimes bleeds and his foot is swollen and he already lost a bone from one of his toes
CubaHeal Team
May 7, 2020 at 2:56 pm
Dear Etratia,
We are forwarding your inquiry to our admin department in order for them to supply with full program details and the cost.
Best regards,
CubaHeal Team
CubaHeal Team
May 7, 2020 at 2:59 pm
Dear Yadira,
We are forwarding your inquiry to our admin department in order for them to supply with full program details and the cost.
Best regards,
CubaHeal Team
Alexander (Last name withheld for privacy reasons)
June 13, 2020 at 12:52 am
Is there way to buy this in US?
Thank you
CubaHeal Team
August 27, 2020 at 12:06 am
Dear Alexander,
This is a prescribed injection which requires the presence of the patient in the Republic of Cuba in order to undergo through and in-depth evaluation and testing. furthermore, in the vast majority of the cases, and prior to applying this injection, the patient will be required to undergo toilet surgery/ surgeries to remove the dead tissues prior to applying the injections into the open area. We are forwarding your inquiry to our admin department in order for them to reach out to you with full details of the treatment/ surgical program, the cost, and the steps the patient is required to follow in order for the admin team to be able to forward a complete medical dossier to the Cuban Medical Authorities (CMA) for evaluation and determination of suitability.
Regards,
CubaHeal team
CubaHeal Client Care
April 6, 2023 at 7:52 pm
Dear Alexander,
Kindly be aware, Heberprot-P is a prescribed medicine. In order for the patient to qualify for treatment of diabetic foot ulcer, the patient must travel to Cuba in order to undergo thorough evaluation and testing prior to the Heberprot-P injections being administered at the hands of highly qualified specialists. Furthermore, and in all likelihood, your mother would need to undergo what is known as “toilet surgeries” (multiple) prior to the injection being applied to the exposed areas.
Yours,
CubaHeal Client care
Dorin
June 15, 2020 at 5:38 pm
Hello,
I am interested in treatment for foot ulcer.
I think is rated 2 – ulcers with exposed tendons and joints.
Thank you
CubaHeal Team
August 26, 2020 at 11:59 pm
Dear Dorin,
Your inquiry has been forwarded to our admin department in order for them to reach out to you with full details of the possible surgical program, the cost, and the steps you are required to follow in order for the admin team to be able to forward your complete medical dossier to the Cuban Medical Authorities (CMA) for evaluation and determination of suitability.
Best regards,
CubaHeal team
Raquel (Last name withheld for privacy reasons)
June 21, 2020 at 10:14 pm
Hola, mi padre esta en el hospital con una infeccion en el pie por un pequeño corte, pero ahora no tiene circulacion en los dedos del pie y tiene un dedo negro y los otros dedos estan comenzando a quedar negro, tiene riesgo de amputacion , el es diabetico y siempre esta alta el azucar , y sufre de tencion alta tambien.. me gustaria un consejo…gracias..
CubaHeal Team
August 26, 2020 at 11:58 pm
Dear Raquel,
Su consulta ha sido enviada a nuestro departamento de administración para que se comuniquen con usted con todos los detalles del posible programa quirúrgico, el costo y los pasos que debe seguir para que el equipo de administración pueda enviar su expediente médico completo a las Autoridades Médicas Cubanas (CMA) para evaluación y determinación de idoneidad.
Atentamente,
CubaHeal Team
CubaHeal Client Care
April 6, 2023 at 7:48 pm
Querida Raquel,
Su consulta ha sido enviada a CHMT LA, que es nuestra compañía hermana que está a cargo de los pacientes latinoamericanos.
Atentamente,
CubaHeal Client Care
Donaldo
October 12, 2020 at 2:21 am
I live in the USA, hoe can i get my hands on the treatment for my grandmother who has a really bad ulcer on her foot?
CubaHeal Client Care
April 6, 2023 at 7:31 pm
Dear Donaldo,
Kindly be aware, Heberprot-P is a prescribed medicine. In order for the patient to qualify for treatment of diabetic foot ulcer, the patient must travel to Cuba in order to undergo thorough evaluation and testing prior to the Heberprot-P injections being administered at the hands of highly qualified specialists. Furthermore, and in all likelihood, your mother would need to undergo what is known as “toilet surgeries” (multiple) prior to the injection being applied to the exposed areas.
Yours,
CubaHeal Client care
zhangkuifeng
October 29, 2020 at 2:32 am
price list; instructions
CubaHeal Client Care
April 6, 2023 at 7:25 pm
Dear zhangkuifeng,
Kindly elaborate on what you mean by “price list/ instructions”
Yours,
CubaHeal Client Care
Amrich
May 17, 2022 at 4:03 am
How can I get this medication for my brother. He has diabetic type 1. We is from Bosnia. Please give me more information how to get this med?
CubaHeal Client Care
June 10, 2022 at 10:12 pm
Dear Amrich,
Your inquiry had been forwarded to our admin department.
Best regards
Monica (Last name omitted for privacy purposes)
June 6, 2022 at 7:05 pm
My father suffers from diabetic ulcers
We would very much like to take part in study or purchase drug
CubaHeal Client Care
June 10, 2022 at 9:50 pm
Dear Monica,
Your inquiry had been forwarded to our admin department.
Best regards
Tatyana (last name withheld for privacy protection)
September 28, 2022 at 1:47 am
Hello,
My aunt suffers from diabetic ulcers, I live in Florida. Where and how can we purchase this medication?
CubaHeal Client care
March 17, 2023 at 11:22 pm
Dear Tatyana,
Kindly be aware, and in order to receive treatment for your aunts’ diabetic ulcers’ condition utilizing Heberprot-P, your aunt’s presence in the Republic of Cuba is a must. This is in order for the patient to undergo thorough evaluation and testing prior to the medicine being prescribed. Any claim of otherwise is most definitely by fraudulent entities trying to take advantage of patients’ vulnerability and the success of Melagenina Plus.
Your inquiry had been forwarded to our admin department in order for them to reach out to you with full details of the treatment/ surgical program, the costs, and the steps you are required to complete in order for the admin team to be able to forward your brother’s complete medical dossier to the Cuban Medical Authorities for evaluation and determination of treatment suitability.
Best regards
Aleksandra (last name withheld for privacy protection)
February 2, 2023 at 10:01 am
I have a friend who needs this treatment. We are in Australia. He lives in Sydney, and he is currently in Westmead hospital. Do you know if Heberprot-P is available in Australia and where can we saurce it from? Kind regards Aleksandra
CubaHeal Client care
March 17, 2023 at 8:30 pm
Dear Aleksandra,
Your inquiry had been forwarded to our admin department in order for them to reach out to you with full details of the treatment/ surgical program, the costs, and the steps you are required to complete in order for the admin team to be able to forward your friend’s complete medical dossier to the Cuban Medical Authorities for evaluation and determination of treatment suitability.
Best regards
Mingzhe
May 12, 2024 at 4:32 am
Hello, I am currently in Ontario Canada, I want to buy this product for my friend’s father living in China, Please tell me how to get this medicine thank you so much.